Author(s) :

Aarav P. Narang.

Volume/Issue :

Abstract :

Alzheimer’s disease is a progressive neurodegenerative disorder characterized by memory loss and cognitive decline. While traditionally associated with amyloid-beta plaques and tau protein tangles, recent research suggests that metabolic dysfunction, particularly impaired insulin signaling in the brain, may play a central role in its development. This supports the hypothesis that Alzheimer’s disease may represent “Type 3 Diabetes.” At the same time, the gut–brain axis has emerged as an important system linking gut microbiota to brain function through immune, metabolic, and neural pathways. This paper examines how gut microbiome dysbiosis may contribute to insulin resistance and Alzheimer’s disease. Evidence suggests that dysbiosis promotes inflammation and disrupts insulin signaling, but causality remains unclear.