Author(s) :

Ananya Thota.

Volume/Issue :

Abstract :

Endometriosis (EMS) is a chronic, estrogen-dependent, and progesterone-resistant inflammatory condition in which endometrial-like tissue is found outside the uterus, affecting 6-10% of reproductive age women. Research has emerged on the genetic and biological associations of EMS, identifying biological pathways such as sex steroid hormone pathways and specific genes that may contribute to the disease phenotype. Despite this, there is uncertainty on how different findings across different scientific disciplines compare and inform the public on EMS pathogenesis. This paper synthesizes f indings from the emerging genetic research and hormonal-associated studies and discusses how these f indings contribute to our existing knowledge of EMS causes and progression. Understanding the intersectionality of biological mechanisms from different regulatory systems, relevant pathways, and how they contribute to the chronic and inflammatory nature of EMS, will deepen our knowledge of the disease pathology. Thus experts should also consider examining EMS from a more interdisciplinary perspective, such as conducting multi-system EMS studies and including diverse populations in EMS research as novel approaches for studying EMS and other reproductive-related diseases.