Author(s) :

Misha Dadlani.

Volume/Issue :

Abstract :

Myocardial Infarction (also commonly known as Heart attack or Cardiac arrest) is a predominant cause of mortality and hospitalization worldwide. Current treatments such as use of stents and open heart surgery carry risks and have their own limitations. However, the use of regenerative medicine offers promising potential and effective treatment therapies using mesenchymal stem cells (MSCs) due to their potent properties and self-renewal capabilities. This literature review does a comprehensive assessment of the studies, research and clinical trials involving MSCs to find a more effective and durable cure for myocardial infarction. The studies and clinical trials conducted worldwide using both allogenic and autologous MSCs show positive signs of myocardium tissue regeneration and improvement of cardiac functions. Positive outcomes carried over a decade of preclinical and clinical trials using MSC therapies to treat myocardial infarction are very promising offering significant potential for cure. Further research and clinical trials are required to standardize protocols for administration of MSCs and provide cohesive guidance on use of optimal dosing, administration routes, and frequency to ensure safety and efficacy of this treatment.