Author(s) :

Saba Brockhagen.

Volume/Issue :

Abstract :

Adolescence is a critical stage of brain development marked by rapid maturation of the prefrontal cortex and hippocampus, regions of the brain responsible for memory, decision-making, and emotional regulation. During this period of heightened neuroplasticity, the brain is especially sensitive to environmental influences, including the use of substances like alcohol, marijuana, and nicotine. This literature review examines how each of these substances disrupts brain development and impairs cognitive function. Alcohol use interferes with synaptic pruning and myelination in the prefrontal cortex, leading to poor impulse control and decision-making. It also causes hippocampal damage, including inflammation and volume loss, which impairs memory encoding and learning. Marijuana’s active compound, THC, disrupts cannabinoid receptor function in the hippocampus, reducing neuroplasticity and leading to structural shrinkage and long-term memory deficits. Marijuana also thins the prefrontal cortex, delaying cognitive control development. Nicotine overstimulates acetylcholine receptors, hindering normal pruning and reducing gray matter volume, especially in the prefrontal cortex and hippocampus. This contributes to attention problems, increased impulsivity, and impaired working memory. Neuroimaging studies consistently show functional and structural differences in adolescents who use these substances compared to non-users. These changes may persist even after substance use stops, increasing the risk of long-term cognitive challenges and future substance use disorders. Early prevention and intervention efforts, such as school-based education and promotion of healthy habits, are essential to reduce adolescent substance use and protect brain development. This review highlights the urgent need for continued research and public health strategies to address the risks associated with early exposure to alcohol, marijuana, and nicotine.