Author(s) :

Mahima Sanghera.

Volume/Issue :

Abstract :

Across all demographics, major depressive disorder (MDD) continues to rank first globally as the most common and often incurable mental health condition. In particular, this study identifies two categories: conventional antidepressants and rapid-acting antidepressants. It analyzes selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) from conventional antidepressants, as well as ketamine and esketamine from rapid-acting antidepressants. Utilizing existing research, this review examines the similarities and differences in the brain region affected by each treatment through neurotransmitters based on the type of antidepressant. The purpose of this review is to compare and contrast how varying antidepressant treatments affect neurotransmitters and how this determines their onset and duration of efficiency.