Author(s) :

Yihao He and Yu Qiu.

Volume/Issue :

Abstract :

The human aspartyl-asparaginyl-β-hydroxylase (HAAH) is typically overexpressed in various types of cancer but remains undetectable or expressed at very low levels in most normal mature tissues. This suggests that HAAH could serve as a potential biomarker for cancer diagnosis. In this study, we examined 23 esophageal carcinoma tissues and 23 adjacent non-tumor tissues using semi-quantitative RT-PCR to detect HAAH mRNA expression. Our findings revealed that HAAH mRNA expression was detectable in all 23 esophageal cancer specimens (100%), while it was absent in 4 adjacent non-tumor tissue samples. Furthermore, HAAH was overexpressed in 17 esophageal carcinoma specimens (73.9%), compared to only 3 normal non-tumor tissue specimens (13%). These results strongly suggest that the HAAH gene is frequently overexpressed in esophageal carcinoma, providing support for its potential as a diagnostic marker for this condition.