The Lifestyle and Environmental Drivers of Circadian Misalignment and Their Implications for Chronic Diseases
Publication Date : May-27-2026
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Abstract :
The circadian rhythm is the body’s internal clock, regulating vital functions and systems such as sleep cycles, hormone release, appetite, digestion, and temperature. Each organ is influenced by circadian timing, while the master clock resides in the brain. The suprachiasmatic nucleus, a cluster of nerve cells in the hypothalamus, coordinates biological processes in response to daylight and helps regulate the master clock’s rhythm. Light signals from the eyes, combined with brain activity, mediate circadian rhythms. However, daily life can disrupt these cycles. This paper reviews common yet detrimental factors that influence the regulation of circadian rhythms. Diet, nutrient intake, and meal timing can disrupt appetite and metabolism. Furthermore, studies have shown that stress, work shifts, screen usage, and poor sleep can all lead to circadian misalignment. This misalignment is associated with chronic health conditions such as obesity, sleep disorders, mental health disorders, heart issues, and cancer.
