Author(s) :

Hannah Zhong.

Volume/Issue :

Abstract :

Induced pluripotent stem cells (iPSCs) hold remarkable potential for regenerative medicine, disease modeling, and drug discovery. The reprogramming of somatic cells into iPSCs has opened new avenues for personalized therapies and understanding human diseases. This review provides a comprehensive overview of iPSC reprogramming methods, highlighting recent advancements, challenges, and future prospects. Various techniques, including viral approaches, episomal vectors, protein transduction, small molecules, and microRNAs, are discussed in detail. Furthermore, strategies to enhance reprogramming efficiency, minimize genomic instability, and improve the quality of iPSCs are explored. The integration of emerging technologies would revolutionize iPSC research and accelerate clinical translation. Overall, this review aims to provide insights into the evolving landscape of iPSC reprogramming methods and their implications for biomedical applications.